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of Clinical Oncology<\/em>\uff0c\u5f71\u54cd\u56e0\u5b50\uff1a45.3\uff09\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u65e2\u5f80\u5316\u7597\u5931\u8d25\u7684\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\uff0c\u60a3\u8005ORR\u4e3a20.5%\uff0cDCR\u4e3a40.0%\uff0c\u4e2d\u4f4dOS\u8fbe17.4\u4e2a\u6708\u3002<\/p>\n\n\n\n<p>\u57fa\u4e8e\u4e0a\u8ff0\u4e24\u9879\u7814\u7a76\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7528\u4e8e\u665a\u671f\u9f3b\u54bd\u764c\u4e00\u7ebf\u548c\u540e\u7ebf\u6cbb\u7597\u76842\u9879\u9002\u5e94\u75c7\u5df2\u5728\u4e2d\u56fd\u83b7\u5f97\u6279\u51c6\uff0c\u662f\u5168\u7403\u9996\u4e2a\u83b7\u6279\u8be5\u9886\u57df\u6cbb\u7597\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u3002\u5728\u56fd\u9645\u4e0a\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u9f3b\u54bd\u764c\u9002\u5e94\u75c7\u9664\u4e86\u5df2\u5728\u7f8e\u56fd\u6279\u51c6\uff0c\u5e76\u83b7\u5f97FDA\u6388\u4e882\u9879\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u548c1\u9879\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c\u76f8\u5173\u9002\u5e94\u75c7\u5728\u6b27\u76df\u548c\u82f1\u56fd\u76d1\u7ba1\u673a\u6784\u7684\u4e0a\u5e02\u7533\u8bf7\u4e5f\u6b63\u5728\u5ba1\u8bc4\u4e2d\u3002<\/p>\n\n\n\n<p><strong>JUPITER-02<\/strong><strong>\u3001<\/strong><strong>POLARIS-02<\/strong><strong>\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f90\u745e\u534e\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201c\u4eca\u5929\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u80fd\u591f\u8d70\u51fa\u56fd\u95e8\u5e76\u83b7\u6279\u6210\u4e3a\u7f8e\u56fd\u9f3b\u54bd\u764c\u6cbb\u7597\u7684\u7b2c\u4e00\u6b3e\u836f\u7269\uff0c\u8fd9\u79bb\u4e0d\u5f00\u4f17\u591a\u4e2d\u56fd\u80bf\u7624\u5b66\u4e13\u5bb6\u5728\u8be5\u5b66\u79d1\u6df1\u8015\u6570\u5341\u5e74\u6253\u4e0b\u7684\u575a\u5b9e\u57fa\u7840\uff0c\u4e5f\u79bb\u4e0d\u5f00\u6240\u6709\u53c2\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u7814\u7a76\u7684\u60a3\u8005\u3001\u7814\u53d1\u56e2\u961f\u7684\u503e\u60c5\u5949\u732e\u3002JUPITER-02\u548cPOLARIS-02\u51fa\u8272\u7684\u7814\u7a76\u6210\u679c\u4e3a\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\/\u5355\u836f\u4f5c\u4e3a\u665a\u671f\u9f3b\u54bd\u764c\u4e00\u7ebf\u81f3\u540e\u7ebf\u6807\u51c6\u7597\u6cd5\u63d0\u4f9b\u4e86\u786e\u51ff\u8bc1\u636e\uff0c\u671f\u5f85\u8fd9\u9879\u2018\u4e2d\u56fd\u65b9\u6848\u2019\u80fd\u591f\u5207\u5b9e\u6539\u53d8\u56fd\u9645\u4e0a\u7f79\u60a3\u9f3b\u54bd\u764c\u4f46\u7f3a\u4e4f\u6709\u6548\u6cbb\u7597\u624b\u6bb5\u7684\u60a3\u8005\u5883\u9047\uff0c\u4e3a\u4ed6\u4eec\u5e26\u6765\u66f4\u597d\u7684\u751f\u5b58\u5e0c\u671b\uff01\u201d<\/p>\n\n\n\n<p><strong>\u541b\u5b9e\u751f\u7269\u9996\u5e2d\u6267\u884c\u5b98\u674e\u5b81\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u4eca\u5929\u6211\u4eec\u8fce\u6765\u4e86\u516c\u53f8\u53c8\u4e00\u9879\u91cd\u8981\u7684\u2018\u51fa\u6d77\u2019\u91cc\u7a0b\u7891\uff0c\u5728\u57c3\u7279\u53f8\u97e6\u5355\u6297\u4e4b\u540e\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u6210\u4e3a\u541b\u5b9e\u751f\u7269\u7b2c\u4e8c\u6b3e\u901a\u8fc7FDA\u6279\u51c6\u5728\u7f8e\u56fd\u5b9e\u73b0\u5546\u4e1a\u5316\u7684\u4ea7\u54c1\uff0c\u8fd9\u4e0d\u4ec5\u610f\u5473\u7740\u6211\u4eec\u7684\u7814\u53d1\u8d28\u91cf\u548c\u751f\u4ea7\u8d28\u91cf\u5747\u83b7\u5f97\u4e86\u56fd\u9645\u76d1\u7ba1\u673a\u6784\u7684\u8ba4\u53ef\uff0c\u4e5f\u5c06\u5f88\u5927\u7a0b\u5ea6\u4e0a\u8fdb\u4e00\u6b65\u63a8\u8fdb\u516c\u53f8\u56fd\u9645\u5316\u5e03\u5c40\u7684\u8fdb\u7a0b\u3002\u76ee\u524d\uff0c\u8be5\u4ea7\u54c1\u7684\u5168\u7403\u5546\u4e1a\u5316\u7f51\u7edc\u5df2\u521d\u6b65\u6210\u5f62\uff0c\u5c06\u8986\u76d6\u8d85\u8fc750\u4e2a\u56fd\u5bb6\u3002\u9075\u5faa\u516c\u53f8\u2018\u7acb\u8db3\u4e2d\u56fd\uff0c\u5e03\u5c40\u5168\u7403\u2019\u7684\u56fd\u9645\u5316\u6218\u7565\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u643a\u624b\u5408\u4f5c\u4f19\u4f34\uff0c\u5168\u529b\u63a8\u52a8\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u66f4\u591a\u5730\u533a\u7684\u5546\u4e1a\u5316\u843d\u5730\uff0c\u4e3a\u66f4\u591a\u6d77\u5916\u60a3\u8005\u63d0\u4f9b\u6765\u81ea\u4e2d\u56fd\u7684\u9ad8\u8d28\u91cf\u521b\u65b0\u836f\u7269\u3002\u201d<\/p>\n\n\n\n<p><strong>\u541b\u5b9e\u751f\u7269\u9996\u5e2d\u533b\u5b66\u5b98Patricia Keegan\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u9996\u4e2a\u6d77\u5916\u4e0a\u5e02\u6279\u51c6\u5f97\u76ca\u4e8e\u541b\u5b9e\u751f\u7269\u7684\u521b\u65b0\u836f\u7814\u53d1\u7b56\u7565\u2014\u2014\u5728\u5173\u6ce8\u4e2d\u56fd\u548c\u4e9a\u6d32\u60a3\u8005\u4e34\u5e8a\u9700\u6c42\u7684\u540c\u65f6\uff0c\u52aa\u529b\u4e3a\u4e2d\u56fd\u4ee5\u5916\u7684\u60a3\u8005\u63d0\u4f9b\u80fd\u591f\u5ef6\u957f\u751f\u547d\u7684\u65b0\u836f\uff0c\u7f29\u5c0f\u5168\u7403\u6cbb\u7597\u5dee\u5f02\u3002\u672c\u6b21\u6279\u51c6\u5bf9\u4e8e\u541b\u5b9e\u751f\u7269\u8fdb\u519b\u5168\u7403\u5e02\u573a\u662f\u4e00\u4e2a\u5f88\u597d\u7684\u5f00\u7aef\u3002\u9664\u4e86\u7279\u745e\u666e\u5229\u5355\u6297\uff0c\u6211\u4eec\u8fd8\u6709\u66f4\u591a\u9887\u6709\u524d\u666f\u7684\u9002\u5e94\u75c7\u548c\u836f\u7269\u6b63\u5728\u5f00\u5c55\u56fd\u9645\u7814\u7a76\u3002\u6211\u4eec\u76f8\u4fe1\uff0c\u516c\u53f8\u65e8\u5728\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u66f4\u6709\u6548\u7684\u65b0\u836f\u6cbb\u7597\u9009\u62e9\u7684\u5b97\u65e8\u5c06\u4e3a\u6211\u4eec\u6210\u957f\u4e3a\u4e00\u5bb6\u56fd\u9645\u578b\u521b\u65b0\u4f01\u4e1a\u63d0\u4f9b\u6e90\u6e90\u4e0d\u65ad\u7684\u52a8\u529b\u3002\u201d<\/p>\n\n\n\n<p><strong>Coherus\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98Denny Lanfear<\/strong>\u8868\u793a\uff1a\u201c\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u83b7\u6279\u662fCoherus\u4f5c\u4e3a\u4e00\u5bb6\u521b\u65b0\u80bf\u7624\u836f\u4f01\u7684\u5173\u952e\u4e8b\u4ef6\u3002\u4f5c\u4e3a\u4e0b\u4e00\u4ee3PD-1\u6291\u5236\u5242\uff0c\u5b83\u662f\u6211\u4eec\u80bf\u7624\u514d\u75ab\uff08I-O\uff09\u6218\u7565\u7684\u57fa\u77f3\uff0c\u65e8\u5728\u5ef6\u957f\u764c\u75c7\u60a3\u8005\u7684\u751f\u5b58\u671f\uff0c\u6b63\u5982\u5b83\u5728\u9f3b\u54bd\u764c\u9886\u57df\u663e\u793a\u51fa\u7684\u4ee4\u4eba\u77a9\u76ee\u7684\u7ed3\u679c\u3002\u6211\u4eec\u611f\u5230\u7279\u522b\u632f\u594b\uff0c\u73b0\u5728\u6b63\u8f6c\u5411\u7279\u745e\u666e\u5229\u5355\u6297\u4e0e\u9776\u5411\u80bf\u7624\u5fae\u73af\u5883\u7684I-O\u836f\u7269\uff08\u5982casdozokitug\u548c\u6211\u4eec\u7684CCR8\u6291\u5236\u5242CHS-114\uff09\u8054\u5408\u4f7f\u7528\uff0c\u53ef\u80fd\u4f1a\u5927\u5927\u62d3\u5c55\u80fd\u591f\u5f97\u5230\u751f\u5b58\u83b7\u76ca\u6539\u5584\u7684\u764c\u75c7\u60a3\u8005\u6570\u91cf\u3002\u201c<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h5>\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n<h5>1. https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/4-Nasopharynx-fact-sheet.pdf.<\/h5>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h6><em>1. <\/em><em>\u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n<h6><em>2. \u82e5\u60a8\u60f3\u4e86\u89e3\u5177\u4f53\u75be\u75c5\u8bca\u7597\u4fe1\u606f\uff0c\u8bf7\u9075\u4ece\u533b\u7597\u536b\u751f\u4e13\u4e1a\u4eba\u58eb\u7684\u610f\u89c1\u4e0e\u6307\u5bfc\u3002<\/em><\/h6>\n\n\n\n<figure class=\"wp-block-image\"><img alt=\"\"\/><\/figure>\n\n\n\n<p><strong>\u5173\u4e8e\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09<\/strong><\/p>\n\n\n\n<p>\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca<sup>\u00ae<\/sup>\uff09\u4f5c\u4e3a\u6211\u56fd\u6279\u51c6\u4e0a\u5e02\u7684\u9996\u4e2a\u56fd\u4ea7\u4ee5PD-1\u4e3a\u9776\u70b9\u7684\u5355\u6297\u836f\u7269\uff0c\u83b7\u5f97\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\u9879\u76ee\u652f\u6301\uff0c\u5e76\u8363\u81ba\u56fd\u5bb6\u4e13\u5229\u9886\u57df\u6700\u9ad8\u5956\u9879\u201c\u4e2d\u56fd\u4e13\u5229\u91d1\u5956\u201d\u3002<\/p>\n\n\n\n<p>\u7279\u745e\u666e\u5229\u5355\u6297\u81f3\u4eca\u5df2\u5728\u5168\u7403\uff08\u5305\u62ec\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u4e1c\u5357\u4e9a\u53ca\u6b27\u6d32\u7b49\u5730\uff09\u5f00\u5c55\u4e86\u8986\u76d6\u8d85\u8fc715\u4e2a\u9002\u5e94\u75c7\u768440\u591a\u9879\u7531\u516c\u53f8\u53d1\u8d77\u7684\u4e34\u5e8a\u7814\u7a76\u3002\u6b63\u5728\u8fdb\u884c\u6216\u5df2\u5b8c\u6210\u7684\u5173\u952e\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u5728\u591a\u4e2a\u7624\u79cd\u8303\u56f4\u5185\u8bc4\u4f30\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u5b89\u5168\u6027\u53ca\u7597\u6548\uff0c\u5305\u62ec\u80ba\u764c\u3001\u9f3b\u54bd\u764c\u3001\u98df\u7ba1\u764c\u3001\u80c3\u764c\u3001\u8180\u80f1\u764c\u3001\u4e73\u817a\u764c\u3001\u809d\u764c\u3001\u80be\u764c\u53ca\u76ae\u80a4\u764c\u7b49\u3002<\/p>\n\n\n\n<p>\u622a\u81f3\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5df2\u5728\u4e2d\u56fd\u83b7\u62796\u9879\u9002\u5e94\u75c7\uff1a\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u5931\u8d25\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\uff082018\u5e7412\u6708\uff09\uff1b\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u7cfb\u7edf\u6cbb\u7597\u5931\u8d25\u7684\u590d\u53d1\/\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u6cbb\u7597\uff082021\u5e742\u6708\uff09\uff1b\u7528\u4e8e\u542b\u94c2\u5316\u7597\u5931\u8d25\u5305\u62ec\u65b0\u8f85\u52a9\u6216\u8f85\u52a9\u5316\u759712\u4e2a\u6708\u5185\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6cbb\u7597\uff082021\u5e744\u6708\uff09\uff1b\u8054\u5408\u987a\u94c2\u548c\u5409\u897f\u4ed6\u6ee8\u7528\u4e8e\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff082021\u5e7411\u6708\uff09\uff1b\u8054\u5408\u7d2b\u6749\u9187\u548c\u987a\u94c2\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\/\u590d\u53d1\u6216\u8fdc\u5904\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff082022\u5e745\u6708\uff09\uff1b\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u7528\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9634\u6027\u3001\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\uff082022\u5e749\u6708\uff09\u30022020\u5e7412\u6708\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u9996\u6b21\u901a\u8fc7\u56fd\u5bb6\u533b\u4fdd\u8c08\u5224\uff0c\u76ee\u524d\u5df2\u67093\u9879\u9002\u5e94\u75c7\u7eb3\u5165\u300a2022\u5e74\u836f\u54c1\u76ee\u5f55\u300b\uff0c\u662f\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u4e2d\u552f\u4e00\u7528\u4e8e\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u7684\u6297PD-1\u5355\u6297\u836f\u7269\u3002<\/p>\n\n\n\n<p>\u5728\u56fd\u9645\u5316\u5e03\u5c40\u65b9\u9762\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5df2\u4f5c\u4e3a\u9996\u6b3e\u9f3b\u54bd\u764c\u836f\u7269\u5728\u7f8e\u56fd\u83b7\u5f97\u6279\u51c6\uff0c\u5176\u5728\u9ecf\u819c\u9ed1\u8272\u7d20\u7624\u3001\u9f3b\u54bd\u764c\u3001\u8f6f\u7ec4\u7ec7\u8089\u7624\u3001\u98df\u7ba1\u764c\u3001\u5c0f\u7ec6\u80de\u80ba\u764c\u9886\u57df\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u4e882\u9879\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u30011\u9879\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\u30011\u9879\u4f18\u5148\u5ba1\u8bc4\u8ba4\u5b9a\u548c5\u9879\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002<\/p>\n\n\n\n<p>2022\u5e7412\u6708\u548c2023\u5e742\u6708\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u548c\u82f1\u56fd\u836f\u54c1\u548c\u4fdd\u5065\u54c1\u7ba1\u7406\u5c40\uff08MHRA\uff09\u5206\u522b\u53d7\u7406\u4e86\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u987a\u94c2\u548c\u5409\u897f\u4ed6\u6ee8\u7528\u4e8e\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u9f3b\u54bd\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u4ee5\u53ca\u8054\u5408\u7d2b\u6749\u9187\u548c\u987a\u94c2\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\/\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u98df\u7ba1\u9cde\u764c\u60a3\u8005\u7684\u4e00\u7e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