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\u5317\u4eac\u65f6\u95f42024\u5e741\u67082\u65e5\uff0c\u541b\u5b9e\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u5e03\uff0c\u7531\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u6297PD-1\u5355\u6297\u836f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca\u00ae<\/sup>\uff09\u8054\u5408\u5316\u7597\u56f4\u624b\u672f\u671f\u6cbb\u7597\uff0c\u7ee7\u4e4b\u672c\u54c1\u5355\u836f\u4f5c\u4e3a\u8f85\u52a9\u6cbb\u7597\uff0c\u7528\u4e8e\u53ef\u5207\u9664IIIA-IIIB\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u6210\u4eba\u60a3\u8005\u7684\u65b0\u9002\u5e94\u75c7\u4e0a\u5e02\u7533\u8bf7\u4e8e\u8fd1\u65e5\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6279\u51c6\u3002\u8fd9\u662f\u7279\u745e\u666e\u5229\u5355\u6297\u5728\u4e2d\u56fd\u83b7\u6279\u7684\u7b2c\u4e03\u9879\u9002\u5e94\u75c7\uff0c\u4e5f\u662f\u6211\u56fd\u9996\u4e2a\u3001\u5168\u7403\u7b2c\u4e8c\u4e2a\u83b7\u6279\u7684\u80ba\u764c\u56f4\u624b\u672f\u671f\u7597\u6cd5\u3002<\/p>\n\n\n\n

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\u8be5\u7814\u7a76\u5171\u7eb3\u5165404\u4f8bIII\u671fNSCLC\u60a3\u8005\uff0c\u4ee51:1\u7684\u6bd4\u4f8b\u88ab\u968f\u673a\u5206\u914d\u81f3\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7ec4\uff08n=202\uff09\u6216\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7ec4\uff08n=202\uff09\uff0c\u5206\u522b\u63a5\u53d7\u7279\u745e\u666e\u5229\u5355\u6297\u6216\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u672f\u524d3\u5468\u671f\u53ca\u672f\u540e1\u5468\u671f\u6cbb\u7597\uff08\u9cde\u764c\u60a3\u8005\u5316\u7597\u65b9\u6848\u4e3a\u7d2b\u6749\u7c7b+\u94c2\u7c7b\uff0c\u975e\u9cde\u764c\u60a3\u8005\u5316\u7597\u65b9\u6848\u4e3a\u57f9\u7f8e\u66f2\u585e+\u94c2\u7c7b\uff09\uff0c\u968f\u540e\u63a5\u53d7\u7279\u745e\u666e\u5229\u5355\u6297\u6216\u5b89\u6170\u5242\u5de9\u56fa\u6cbb\u759713\u5468\u671f\u3002<\/p>\n\n\n\n

\u6b64\u524d\uff0cNEOTORCH\u57282023\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5168\u4f53\u5927\u4f1a\u7cfb\u52174\u6708\u4f1a\u8bae\u4ee5\u53caASCO\u5e74\u4f1a\u4e0a\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u516c\u5e03\u4e86\u6700\u65b0\u7814\u7a76\u6210\u679c\u3002\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u76f8\u8f83\u5355\u7eaf\u5316\u7597\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u5316\u7597\u7528\u4e8e\u53ef\u624b\u672fIII\u671fNSCLC\u56f4\u624b\u672f\u671f\u6cbb\u7597\u53ef\u663e\u8457\u5ef6\u957f\u60a3\u8005\u7684EFS\uff08\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u4e2d\u4f4dEFS\u5206\u522b\u4e3a\uff1a\u5c1a\u672a\u6210\u719f vs 15.1\u4e2a\u6708\uff0cP<0.0001\uff09\uff0c\u5c06\u60a3\u8005\u7684\u75be\u75c5\u590d\u53d1\u3001\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8660%\uff08HR=0.40\uff0c95%CI\uff1a0.277-0.565\uff0c\u53cc\u4fa7P<0.0001\uff09\uff0c\u4e14\u4e0d\u8bbaPD-L1\u8868\u8fbe\u72b6\u6001\u3001\u7ec4\u7ec7\u5b66\u7c7b\u578b\uff08\u9cde\u72b6\u6216\u975e\u9cde\u72b6\uff09\u5982\u4f55\uff0c\u6240\u6709\u5173\u952e\u4e9a\u7ec4\u4e2d\u5747\u89c2\u5bdf\u5230\u7279\u745e\u666e\u5229\u5355\u6297\u7ec4\u7684EFS\u83b7\u76ca\u3002\u7279\u745e\u666e\u5229\u5355\u6297\u7ec4\u7684\u4e3b\u8981\u75c5\u7406\u7f13\u89e3\uff08MPR\uff09\u7387\u548c\u5b8c\u5168\u75c5\u7406\u7f13\u89e3\uff08pCR\uff09\u7387\u660e\u663e\u66f4\u4f18\uff0c\u5206\u522b\u4e3a48.5% vs 8.4%\uff08P\uff1c0.0001\uff09\u548c24.8% vs 1.0%\uff08P\uff1c0.0001\uff09\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u7ec4\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4e5f\u663e\u793a\u51fa\u660e\u663e\u7684\u83b7\u76ca\u8d8b\u52bf\u3002\u5b89\u5168\u6027\u65b9\u9762\uff0c\u4e24\u7ec4\u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u53d1\u751f\u7387\u76f8\u4f3c\uff0c\u672a\u89c2\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002<\/p>\n\n\n\n

\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u80f8\u79d1\u533b\u9662\u9646\u821c\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201cNEOTORCH\u7814\u7a76\u5f00\u521b\u4e86\u5168\u7403\u9996\u4e2a\u20183+1+13\u2019NSCLC\u56f4\u672f\u671f\u6cbb\u7597\u65b0\u6a21\u5f0f\uff0c\u60a3\u8005\u7684pCR\u548cMPR\u7387\u8f83\u5355\u7eaf\u5316\u7597\u7ec4\u5206\u522b\u63d0\u5347\u8fd125\u500d\u548c6\u500d\uff0c\u540c\u65f6\u5e26\u6765\u66f4\u9ad8\u7684R0\u5207\u9664\u7387\uff0c\u4e14\u672a\u589e\u52a0\u60a3\u8005\u624b\u672f\u98ce\u9669\uff0c\u800c\u672f\u540e\u8865\u8db31\u5468\u671f\u514d\u75ab\u6cbb\u7597\u8054\u5408\u5316\u7597\uff0c\u4ee5\u53ca\u5e76\u7528\u7279\u745e\u666e\u5229\u5355\u6297\u7ef4\u6301\u6cbb\u7597\u4e00\u5e74\uff0c\u8fdb\u4e00\u6b65\u6d88\u9664\u4e86\u60a3\u8005\u624b\u672f\u540e\u7684\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff0c\u8ba9\u672a\u5b9e\u73b0pCR\u7684\u60a3\u8005\u4e5f\u80fd\u4ece\u6cbb\u7597\u4e2d\u83b7\u76ca\uff0cEFS HR\u4e3a0.40\uff0c\u662f\u76ee\u524d\u62a5\u9053\u7684\u56f4\u624b\u672f\u671f\u514d\u75ab\u6cbb\u7597\u7814\u7a76\u4e2dHR\u4e0b\u964d\u6700\u4e3a\u660e\u663e\u7684\u3002\u76f8\u4fe1\u968f\u7740\u6211\u56fd\u9996\u4e2a\u80ba\u764c\u56f4\u624b\u672f\u671f\u514d\u75ab\u6cbb\u7597\u9002\u5e94\u75c7\u7684\u83b7\u6279\uff0c\u5fc5\u5c06\u6539\u5584\u4e2d\u56fdIII\u671fNSCLC\u60a3\u8005\u7684\u957f\u671f\u751f\u5b58\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u66f4\u591a\u6cbb\u6108\u53ef\u80fd\uff0c\u540c\u65f6\u5c06\u5927\u5e45\u63d0\u5347\u6211\u56fdNSCLC\u7684\u6cbb\u7597\u6c34\u5e73\uff0c\u5efa\u7acb\u56f4\u672f\u671f\u6cbb\u7597\u65b0\u6807\u6746\u3002\u201d<\/p>\n\n\n\n

\u541b\u5b9e\u751f\u7269\u5168\u7403\u7814\u53d1\u603b\u88c1\u90b9\u5efa\u519b\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u6b64\u6b21\u80ba\u764c\u56f4\u624b\u672f\u671f\u65b0\u9002\u5e94\u75c7\u7684\u83b7\u6279\u6807\u5fd7\u7740\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u6cbb\u7597\u4eba\u7fa4\u6b63\u5f0f\u4ece\u665a\u671f\u62d3\u5c55\u5230\u4e86\u65e9\u671f\u80bf\u7624\u60a3\u8005\u3002\u541b\u5b9e\u751f\u7269\u5728\u56f4\u624b\u672f\u671f\u514d\u75ab\u6cbb\u7597\u9886\u57df\u5e03\u5c40\u975e\u5e38\u65e9\uff0c\u4e5f\u662f\u6700\u5148\u5728\u56fd\u5185\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3001\u8986\u76d6\u9002\u5e94\u75c7\u6700\u5e7f\u7684\u672c\u571f\u836f\u4f01\u4e4b\u4e00\u3002\u5982\u4eca\uff0c\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5df2\u6210\u4e3a\u8bf8\u591a\u665a\u671f\u80bf\u7624\u6cbb\u7597\u7684\u6807\u51c6\u7597\u6cd5\uff0c\u6211\u4eec\u76f8\u4fe1\u8fd9\u7c7b\u65b0\u5174\u7597\u6cd5\u4e5f\u5c06\u8fdb\u4e00\u6b65\u4e3a\u65e9\u671f\u80bf\u7624\u6cbb\u7597\u5e26\u6765\u7a81\u7834\u6027\u7684\u53d8\u9769\uff0c\u6210\u4e3a\u60a3\u8005\u83b7\u5f97\u957f\u671f\u83b7\u76ca\u7684\u6f5c\u5728\u4f18\u9009\u65b9\u6848\uff01\u201d<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3010\u53c2\u8003\u6587\u732e\u3011<\/h5>\n\n\n\n
1. https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/15-Lung-fact-sheet.pdf.<\/h5>\n\n\n\n
2. https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf.<\/h5>\n\n\n\n
3. Molina JR, et al. Mayo Clin. Proc. 2008; 83(5), 584\u2013594.<\/h5>\n\n\n\n
4. Liang Y, et al.\u00a0 Transl Lung Cancer Res 2013;2:403-10.<\/h5>\n\n\n\n
5. Uramoto H, et al. Transl Lung Cancer Res 2014;3:242-9.<\/h5>\n\n\n\n
6. Taylor MD, et al. Ann Thorac Surg 2012;93:1813-20.<\/h5>\n\n\n\n
7. Pignon JP, et al. J Clin Oncol 2008; 26:3552-3559.<\/h5>\n\n\n\n
8. NSCLC Meta-analysis Collaborative Group. Lancet 2014 ;383(9928):1561-71.<\/h5>\n\n\n\n

<\/p>\n\n\n\n

1. \u672c\u6750\u6599\u65e8\u5728\u4f20\u9012\u524d\u6cbf\u4fe1\u606f\uff0c\u65e0\u610f\u5411\u60a8\u505a\u4efb\u4f55\u4ea7\u54c1\u7684\u63a8\u5e7f\uff0c\u4e0d\u4f5c\u4e3a\u4e34\u5e8a\u7528\u836f\u6307\u5bfc\u3002<\/em><\/em><\/h6>\n\n\n\n
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